Rabbit polyclonal Human NFKB p65 antibody Background: In 1986, a transcription factor binding to an enhancer region that is necessary to express immunoglobulin kappa light chain gene on mature B cells was identified, and it was named nuclear factor KB (NFKB, nuclear factor of kappa light chain gene enhancer in B cells). Afterwards, it was clarified that NFKB is two hetero dimeric forms of p50 and p65, and it was also found that each molecule has high homology with cRel (oncoprotein of avian retrovirus (reticuloendothelios
is virus strain T) that induces a tumor to the spleen) by cDNA cloning. Nowadays, NFKB is classified into Rel family proteins. In a cell signaling system, NFKB forms a complex with IKB in the cytoplasm, and it is inactivated. It is thought that NFKB is a transcription factor distributed in many kinds of cells.
Rabbit polyclonal Human NFKB p65 antibody
Background:
In 1986, a transcription factor binding to an enhancer region that is necessary to express immunoglobulin kappa light chain gene on mature B cells was identified, and it was named nuclear factor KB (NFKB, nuclear factor of kappa light chain gene enhancer in B cells). Afterwards, it was clarified that NFKB is two hetero dimeric forms of p50 and p65, and it was also found that each molecule has high homology with cRel (oncoprotein of avian retrovirus (reticuloendotheliosis virus strain T) that induces a tumor to the spleen) by cDNA cloning. Nowadays, NFKB is classified into Rel family proteins. In a cell signaling system, NFKB forms a complex with IKB in the cytoplasm, and it is inactivated. It is thought that NFKB is a transcription factor distributed in many kinds of cells.
