Rabbit polyclonal Human LGP2 antibody Background: A full length cDNA encoding mouse LGP2 was cloned by computational analysis, RTPCR, and RACE of liver and mammary tissue total RNA. Human LGP2 was also cloned. Yoneyama et al. have identified a DExD/Hbox-containing RNA helicase, retinoic acid inducible gene I (RIGI), as an essential component of the sensor of intracellular dsRNA. Furthermore, two other DexD/Hbox-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database. MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIGI/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.
Rabbit polyclonal Human LGP2 antibody
Background:
A full length cDNA encoding mouse LGP2 was cloned by computational analysis, RTPCR, and RACE of liver and mammary tissue total RNA. Human LGP2 was also cloned. Yoneyama et al. have identified a DExD/Hbox-containing RNA helicase, retinoic acid inducible gene I (RIGI), as an essential component of the sensor of intracellular dsRNA. Furthermore, two other DexD/Hbox-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database. MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIGI/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.
