Fitzgerald Industries International, Inc. SOCS3 antibody 70R-7655

Description
Rabbit polyclonal Human SOCS3 antibody Background: The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein 3 (CIS3/SOCS3/SSI3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BFER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPOdependent proliferation and STAT5 activation. It is reported that JAB/SOCS1 is strongly induced by interferongamma and forced expression of JAB/SOCS1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS1 knockout mice revealed that JAB/SOCS1 is indeed a "negative feedback regulator" that determines the sensitivity of cells to IFN gamma.
Description
Rabbit polyclonal Human SOCS3 antibody Background: The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein 3 (CIS3/SOCS3/SSI3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BFER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPOdependent proliferation and STAT5 activation. It is reported that JAB/SOCS1 is strongly induced by interferongamma and forced expression of JAB/SOCS1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS1 knockout mice revealed that JAB/SOCS1 is indeed a "negative feedback regulator" that determines the sensitivity of cells to IFN gamma.

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Fitzgerald Industries International, Inc.
Acton, MA, USA
SOCS3 antibody
70R-7655
SOCS3 antibody 70R-7655
Rabbit polyclonal Human SOCS3 antibody Background: The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein 3 (CIS3/SOCS3/SSI3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BFER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPOdependent proliferation and STAT5 activation. It is reported that JAB/SOCS1 is strongly induced by interferongamma and forced expression of JAB/SOCS1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS1 knockout mice revealed that JAB/SOCS1 is indeed a "negative feedback regulator" that determines the sensitivity of cells to IFN gamma.

Rabbit polyclonal Human SOCS3 antibody
Background:
The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein 3 (CIS3/SOCS3/SSI3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BFER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPOdependent proliferation and STAT5 activation. It is reported that JAB/SOCS1 is strongly induced by interferongamma and forced expression of JAB/SOCS1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS1 knockout mice revealed that JAB/SOCS1 is indeed a "negative feedback regulator" that determines the sensitivity of cells to IFN gamma.

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Technical Specifications

  Fitzgerald Industries International, Inc.
Product Category Biological Materials
Product Number 70R-7655
Product Name SOCS3 antibody
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