Sheep polyclonal PAI1 antibody (HRP) conjugated
Background:
PAI1 is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFa, glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases.
| Fitzgerald Industries International, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | 60R-1079 |
| Product Name | PAI1 antibody (HRP) |