A synthetic peptide for use as a blocking control in assays to test for specificity of FHIT antibody, catalog no. 70R-4587 Background: This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-tripho
sphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
A synthetic peptide for use as a blocking control in assays to test for specificity of FHIT antibody, catalog no. 70R-4587
Background:
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
