Fitzgerald Industries International, Inc. CDKN2B Blocking Peptide 33R-7871

Description
A synthetic peptide for use as a blocking control in assays to test for specificity of CDKN2B antibody, catalog no. 70R-10487 Background: CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.
Description
A synthetic peptide for use as a blocking control in assays to test for specificity of CDKN2B antibody, catalog no. 70R-10487 Background: CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.

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Fitzgerald Industries International, Inc.
Acton, MA, USA
CDKN2B Blocking Peptide
33R-7871
CDKN2B Blocking Peptide 33R-7871
A synthetic peptide for use as a blocking control in assays to test for specificity of CDKN2B antibody, catalog no. 70R-10487 Background: CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.

A synthetic peptide for use as a blocking control in assays to test for specificity of CDKN2B antibody, catalog no. 70R-10487
Background:
CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.

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Technical Specifications

  Fitzgerald Industries International, Inc.
Product Category Biological Materials
Product Number 33R-7871
Product Name CDKN2B Blocking Peptide
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