Rabbit polyclonal NFT antibody Background: The neurofibrillary tangles (NFT) are neuronal inclusions that are the hallmark lesions of Alzheimer's disease (AD). These tangles are made up of paired helical filaments (PHF). The PHF are highly insoluble structures and are known to be composed of a highly phosphorylated form of the microtubule-associat
ed protein tau and may contain associated lipid. Insoluble NFT which were extracted in boiling sodium dodecyl sulfate, purified by sucrose gradient centrifugation and disaggregated by sonication were used as an immunogen for the preparation of this antiserum.
Rabbit polyclonal NFT antibody
Background:
The neurofibrillary tangles (NFT) are neuronal inclusions that are the hallmark lesions of Alzheimer's disease (AD). These tangles are made up of paired helical filaments (PHF). The PHF are highly insoluble structures and are known to be composed of a highly phosphorylated form of the microtubule-associated protein tau and may contain associated lipid. Insoluble NFT which were extracted in boiling sodium dodecyl sulfate, purified by sucrose gradient centrifugation and disaggregated by sonication were used as an immunogen for the preparation of this antiserum.
