Mouse polyclonal Human Reticulocalbin 1 antibody Background: Human Reticulocalbin 1 is a 44kDa protein and belongs to the EF (elongation factor) and calcium binding protein family, and it is known as a luminal protein of endoplasmic reticulum (ER) with the C-terminal HDEL (ER retention signal) sequence. Although it is known that the protein contains six repeated domains each of which has an EF-hand motif, the function of them has not been clalified clearly. In analysis of tumor cells, higher expression of Reticulocalbin 1 is reported in hepatocellular carcinoma than normal hepatocytes and the study suggests the possibility of its involvement in malignancy of human cells through calcium regulation, but there are few reports regarding the expression of Reticulocalbin 1 in oncology. One study reports that Reticulocalubin1 has been found to be highly expressed in cultured cells of highly invasive breast cancer, while it has not been found in low invasive cells, however, its significance is not altogether clear. One of the anticancer drugs most commonly used is cisplatin. Currently, cisplatin (cisdiamminedichloro
platinum (II); cisDDP) is a principal drug of cancer chemotherapy, and it shows beneficial effects in some solid cancers such as head and neck cancer, testicular tumor, ovary cancer and smallcell lung cancer. Hirano et al. reported that in research of markers of anticancer drug sensitivity, they compared the protein expression of cisplatinresistant cell strains and its parent strains using twodimensional electrophoresis and found a spot which was markedly decreased in expression, and then, the analysis of amino acid sequence showed that the spot was Reticulocalbin1.
Mouse polyclonal Human Reticulocalbin 1 antibody
Background:
Human Reticulocalbin 1 is a 44kDa protein and belongs to the EF (elongation factor) and calcium binding protein family, and it is known as a luminal protein of endoplasmic reticulum (ER) with the C-terminal HDEL (ER retention signal) sequence. Although it is known that the protein contains six repeated domains each of which has an EF-hand motif, the function of them has not been clalified clearly. In analysis of tumor cells, higher expression of Reticulocalbin 1 is reported in hepatocellular carcinoma than normal hepatocytes and the study suggests the possibility of its involvement in malignancy of human cells through calcium regulation, but there are few reports regarding the expression of Reticulocalbin 1 in oncology. One study reports that Reticulocalubin1 has been found to be highly expressed in cultured cells of highly invasive breast cancer, while it has not been found in low invasive cells, however, its significance is not altogether clear. One of the anticancer drugs most commonly used is cisplatin. Currently, cisplatin (cisdiamminedichloroplatinum (II); cisDDP) is a principal drug of cancer chemotherapy, and it shows beneficial effects in some solid cancers such as head and neck cancer, testicular tumor, ovary cancer and smallcell lung cancer. Hirano et al. reported that in research of markers of anticancer drug sensitivity, they compared the protein expression of cisplatinresistant cell strains and its parent strains using twodimensional electrophoresis and found a spot which was markedly decreased in expression, and then, the analysis of amino acid sequence showed that the spot was Reticulocalbin1.
