Alpha Diagnostic International, Inc. Rat Thyroid Iodide Transporter (TIT) Control/blocking peptide TIT11-P

Rat Thyroid Iodide Transporter (TIT) Control/blocking peptide General Information Iodide (I-) is an essential constituent of thyroid hormones. Thyroid epithelial cells for the biosynthesis of thyroid hormones actively transport it. At the cellular level, Iodide transport is mediated by intrinsic membrane Na+/I+ symporter (NIS/TIT). SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Rat Form Antigen/blocking Peptide Antigen 16-aa peptide from rat TIT (1); Designation (TIT11-P or control peptide/blocking peptide) conjugated to KLH; Epitope location~ C-terminal, Cytoplasmic domain SpCrossreactivity The 16-aa rat TIT11-P peptide sequence is unique to TIT and no significant sequence is seen with glucose transporter or other Na+-dependent transporters. TIT11-P sequence is 100% conserved in mouse, and only 25% in human TIT. Antibody cross-reactivity in various species has not been studied For research use only, not for diagnostic or therapeutic use.