Alpha Diagnostic International, Inc. Rat TNF-alpha Converting Enzyme (TACE) Control/blocking peptide TACE11-P

Rat TNF-alpha Converting Enzyme (TACE) Control/blocking peptide General Information Recently TACE, a member of the ADAM family (A Disintegrin And Metalloprotease family) protease has been shown to play a central role in a regulated cleavage of human APP. Inhibition of TACE affects both APP secretion and A formation in cultured cells (1 SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Rat Form Antigen/blocking Peptide Antigen 17aa peptide of rat TACE; Designated (TACE11-P or control peptide) conjugated to KLH; epitope location ~C-terminus, extracellular domain SpCrossreactivity The rat TACE11-P peptide sequence is 100% conserved in mouse, and 94% in human TACE. No significant sequence homology exists with other proteases. Antibody crossreactivity in various species is not established. For research use only, not for diagnostic or therapeutic use.