Alpha Diagnostic International, Inc. Anti-Human Receptor Activity Modifying Protein 1 (RAMP1) antiserum #1 RAMP11-S

Anti-Human Receptor Activity Modifying Protein 1 (RAMP1) antiserum #1 General Information The calcitonin family peptides probably act through G-protein coupled membrane receptors. The gene for calcitonin receptors has been cloned. It is homologous to GPCRs in family ?B? which typically recognizes regulatory peptides (secretin, glucagons, VIP SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Human SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Antiserum Unpurified SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen A mixture of 19-aa peptide near extracellular, N-terminus of human RAMP1 (protein accession #O60894, and & 11-aa peptide, cytoplasmic C-terminus of human RAMP1 (protein accession # O60894). The mixture of two peptides are Designated (RAMP11-P or control/blocking peptide). SpCrossreactivity The RAMP11-P peptides are 94% conserved in monkey, 68% in bovine, 57% in pig, 92% in mouse, rat/rabbit, 85% in Zebra fish. and Frog RAMP1. No significant sequence homology is detected with other RAMPs. Antibody cross-reactivity in various species has not been studied. The RAMP11-P Control peptide, because of its low mol. Wt (<3 kDa), is not suitable for Western For research use only, not for diagnostic or therapeutic use.