Alpha Diagnostic International, Inc. Human Receptor Activity Modifying Protein 1 (RAMP1) Control/blocking peptide #1 RAMP11-P

Human Receptor Activity Modifying Protein 1 (RAMP1) Control/blocking peptide #1 General Information The calcitonin family peptides probably act through G-protein coupled membrane receptors. The gene for calcitonin receptors has been cloned. It is homologous to GPCRs in family ?B? which typically recognizes regulatory peptides (secretin, glucagons, VIP SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen A mixture of 19-aa peptide near extracellular, N-terminus of human RAMP1 (protein accession #O60894, and & 11-aa peptide, cytoplasmic C-terminus of human RAMP1 (protein accession # O60894). The mixture of two peptides are Designated (RAMP11-P or control/blocking peptide). SpCrossreactivity The RAMP11-P peptides are 94% conserved in monkey, 68% in bovine, 57% in pig, 92% in mouse, rat/rabbit, 85% in Zebra fish. and Frog RAMP1. No significant sequence homology is detected with other RAMPs. Antibody cross-reactivity in various species has not been studied. The RAMP11-P Control peptide, because of its low mol. Wt (<3 kDa), is not suitable for Western For research use only, not for diagnostic or therapeutic use.