Alpha Diagnostic International, Inc. Anti-Human PUMA-alpha (p53-upregulated modulator of apoptosis) antiserum #1 PUMA12-S

Anti-Human PUMA-alpha (p53-upregulated modulator of apoptosis) antiserum #1 General Information The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. P53 tumor-s SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Human SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Antiserum Unpurified SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen 17-aa, Human PUMA (1) Designation (PUMA12-P, control peptide) coupled to KLH Epitope location ~ Internal (middle region) SpCrossreactivity Human PUMA12-P control peptide sequence is also found in alternatively spliced PUMA-beta but not in gamma or delta forms. PUMA12-P is 88% conserved in mouse and rat PUMA-alpha. No significant sequence homology is detected with other proteins. Antibody cross-reactivity in various species has not been studied. For research use only, not for diagnostic or therapeutic use.