Alpha Diagnostic International, Inc. Anti-Human Presenilin 1 (PS-1) antiserum # 3 PS13-S

Anti-Human Presenilin 1 (PS-1) antiserum # 3 General Information An early onset of FAD has also been linked to some 30 mutations in two related genes, Presenilins-1 (PS-1 on chromosome 14; 467 aa) and Presenilins-2 (PS-2 on chromosome 1; 448 aa). Presenilins may contain 7-9 transmembrane domains. Presenilins are member SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2479-seconda ry-antibodies-goat.h tm SpeciesReactivity Human SugNegativeControl Non-immune Goat IgG Cat# 20011-1 Form Antiserum Unpurified SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen 20-aa peptide from human PS-1 (1); Designation (PS13-P, control peptide) conjugated to KLH; epitope location ~ N-terminus, Extracellular domain SpCrossreactivity The immunogenic peptide sequences from Presenilin-1, PS13-P shows 100% homology to monkey, lemur, 95% with bovine, 70% with mouse, and 80% with rat PS1. No significant homology exists with PS2 or other known proteins. Antibody cross-reactivity in various species has not been studied For research use only, not for diagnostic or therapeutic use.