Alpha Diagnostic International, Inc. Anti-Human Parkin antiserum PARK11-S

Anti-Human Parkin antiserum General Information Parkin is a 465aa (isoforms 1) protein in human (chrm 6q25.2-q27) and mouse, expressed in many tissues, including brain, heart, testis, and skeletal muscle. Parkin isoforms 2 (437-aa) lacks exon 5 (19-206 aa) and the isoforms 3 (316 aa) lacks exons 3-5. SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Human SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Antiserum Unpurified SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen 23-aa peptide of human PARK isoform 1 Designated (PARK11-P or control peptide). conjugated to KLH; epitope location ~ C-terminus SpCrossreactivity Human PARk11-P peptide sequence is conserved in alternatively spliced isoforms (isoform 1, 465 aa; isoforms 2, 437 aa; and isoform 3, 316 aa;;). It is also highly conserved in mouse and rat (95%), and drosophila?s Parkin (69%). No significant homology of PARK11-P is seen with ubiquitin or any other proteins. Antibody cross-reactivity with Parkin from other species is not known For research use only, not for diagnostic or therapeutic use.