Alpha Diagnostic International, Inc. human acetylated p53 (K-320) Control/blocking peptide P53A320-P

human acetylated p53 (K-320) Control/blocking peptide General Information Posttranslational modifications of p53 (phosphorylation and acetylation) have been implicated in its physiological role. p53 has at least 4 phosphorylation sites at the N-terminus with Ser15 as an important site in response to DNA damage and a target of SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen A peptide (designated P53A320-P, control peptide) surrounding the human p53, acetylated at Lys320, was coupled to KLH; Lysine320 is acetylated by PCAF SpCrossreactivity P53A320 antibody recognizes only p53 acetylated at K320 residue. It does not react with non-acetylated p53 or unrelated proteins. It recognizes recombinant mouse and rat p53 as well. No crossreactivity is seen with p63 or p73. Antibody crossreactivity in various species is not established For research use only, not for diagnostic or therapeutic use.