Alpha Diagnostic International, Inc. Orexin-A full length 1-33 aa (Mouse/rat/Human), Cyclized OXA12-P-05

Orexin-A full length 1-33 aa (Mouse/rat/Human), Cyclized General Information Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (1-2). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is 130 amino acid long peptide with a putative 33 AA secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (1-2). These neuropeptides bind and activate two closely related Orexin receptors--G-protein coupled receptors (GPCRs) OX1R and OX2R. Rat and human OX1R are 416 aa, and 425 aa, respectively (1-2) SpeciesReactivity Mouse/Rat/Human Antigen Mouse/rat/human Orexin-A is 33-aa peptide. Full length Orexin-A peptide (designated OXA12-P) corresponding to 1-33 aa ( Form Pure Peptide For research use only, not for diagnostic or therapeutic use.