Alpha Diagnostic International, Inc. Rat Na-Ca Exchanger 1 (NCX1) Control/blocking peptide #2 NCX12-P

Rat Na-Ca Exchanger 1 (NCX1) Control/blocking peptide #2 General Information NCX1 (rat 971 aa, human 970 aa, mouse 970 aa) is most prominently expressed in the heart where it plays a major role in excitation-contracti on coupling, but is also present in most other tissues. Alternative spicing of NCX1/NACA1 produces numerous tissue SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Rat Form Antigen/blocking Peptide Antigen 23-aa peptide of Rat (gene accession # S32345) NCX1 ; Designated (NCX12-P or control peptide pr blocking peptide) conjugated to KLH; epitope location ~ N-terminal, Cytoplasmic domain SpCrossreactivity The 23 AA rat NCX12-P control peptide 100% conserved in mouse, dog, cat, 95% in human, rabbit, monkey, bovine, 86% in chicken, and 73% in frog NCX1. NCX11-P epitope is conserved in NCX isoforms 1-7 that have deletions or substitutions after ~600 aa. No significant sequence homology is detected with other NCX. Antibody cross-reactivity in various species has not been studied For research use only, not for diagnostic or therapeutic use.