Alpha Diagnostic International, Inc. Anti-Mouse/human beta-Defensin 3, IgG #1, aff pure MBD31-A

Anti-Mouse/human beta-Defensin 3, IgG #1, aff pure General Information The genes encoding human a and ß -defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated a ? and ß - based on distinctive, although similar, tri-disulfide linkages in the peptides. -def SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Mouse SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Affinity purified IgG SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen Human beta-defensin-3 is produced from 67 aa peptide precursor (mature peptide 23-67 aa). Mouse beta-defensin-3 is produced from a 63 aa peptide precursor (mature peptide 23-63 aa). A 13 aa peptide mapping at the N-terminus of mature mouse defensin-3 and a 15-aa peptide mapping at the N-terminus of mature human defensin-3. The two peptide were mixed (designated MBD31-P; control peptides) SpCrossreactivity The mouse and human defensin-3 peptides (MBD31-P) used for antibody (MBD31-S or MBD31-A) production are specific for mouse and human defensin-3. The resulting antibodies reacts with both mouse and human defensin-3 but not other beta-defensins. The MBD31-P control peptide is available for antibody blocking to confirm specificity of antibodies. It is not suitable for testing by Western due to small size. Antibody cross-reactivity in various species has not been studied For research use only, not for diagnostic or therapeutic use.