Alpha Diagnostic International, Inc. Human K-Cl Cotransporter 3 (KCC3) Control/blocking peptide #1 KCC31-P

Human K-Cl Cotransporter 3 (KCC3) Control/blocking peptide #1 General Information The K-Cl cotransporters mediate the coupled movement of K+ and Cl- ions across the cell membranes. This transport process is involved in the regulatory volume decrease in response to cell swelling in red cells and vectorial movement of Cl- ions across th SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen 19-aa peptide of Human KCC3 ; (Gene Accession #NP005126.1) Designated (KCC31-P or control peptide or blocking peptide) conjugated to KLH; epitope location ~ N-terminal, Cytoplasmic domain SpCrossreactivity Human KCC31-P antigenic peptide sequence is found in one of the alternatively spliced form (KCC-3b). KCC31-P is 89% conserved in rat and 78% in mouse KCC-3b. The other form of the human KCC3a (1150 aa; Mount DB et al 1999) does not share this sequence. We have raised another antibody (cat # KCC32-S) using the C-terminal peptide sequence that is found in both forms of KCC3. KCC31-P has no significant sequence homology with other KCCs or CCC. Antibody crossreactivity in various species is not established For research use only, not for diagnostic or therapeutic use.