Alpha Diagnostic International, Inc. Human Alpha Defensin 5 (NP-5),control/blocking peptide #1 HDEFA51-P

Human Alpha Defensin 5 (NP-5),control/block ing peptide #1 General Information -defensins are encoded by genes designated DEFA1-6, whereas human -defensins are encoded by the DEFB1 and DEFb2 genes. HD1-4 are expressed in neutrophils, whereas HD5 and HD6 are expressed in epithelial cells of the intestinal and reproductive tract. SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen Human alpha 5 defensins (HDEFA5 or HNP-5) is synthesized from 94 precursor (mature peptide 65-94). A 17-aa peptide (designated HDEFA51-P; control peptides) sequence near the C-terminus of human mature alpha defensin-5 (1) was selected for antibody production. SpCrossreactivity The HDEFA51-P control peptides is specific for human alpha defensin-5. No significant homology exists with other alpha-defensins. The HDEFA51-P control peptide is available for antibody blocking to confirm specificity of antibodies. Antibody cross-reactivity in various species has not been studied. For research use only, not for diagnostic or therapeutic use.