Alpha Diagnostic International, Inc. Anti-Human Hyperpolarization-activated Cyclic Nucleotide-gated channel 1 (HCN1-pore) IgG, aff pure HCNP15-A

Anti-Human Hyperpolarization-ac tivated Cyclic Nucleotide-gated channel 1 (HCN1-pore) IgG, aff pure General Information HCN channels pass both Na+ and K+ with relative permeability ratio of ~0.15 to 0.25. The primary sequence of HCN pore region is clearly related to that of highly selective K+ channels. In contrast to nonselective CNG or Na+-channels, both K+ and HCN cha SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Human/Mouse/Rat SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Affinity purified IgG SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen 23-aa (SYA LFK AMS HML CIG YGA QAP VS, human HCN1 pore 225-247-aa; designated HCNP15-P or control peptide /blocking peptide) conjugated to KLH; ~ pore region SpCrossreactivity The pore region of HCN1 (HCNP15-P) is very conserved among various HCNs. HCN1: mouse, rat, human, rabbit=100%; HCN2: mouse, rat, human (86%); HCN3: mouse (95%), rat (90%); HCN4: rat, human (95%). The HCNP15-P sequence is also conserved in insect (Helothis virescens, 78%), Drosophila (78%) and Sea urchin (S. purpuratus, 69%) HCNs. Therefore, antibodies to HCNP15-P should react with most HCNs and related sequences. Antibody reactivity in various species is not known. For research use only, not for diagnostic or therapeutic use.