Alpha Diagnostic International, Inc. Human beta-Defensin 3 (BD-3) control/blocking peptide #1 HBD31-P

Human beta-Defensin 3 (BD-3) control/blocking peptide #1 General Information The genes encoding human a and ß -defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated a ? and ß - based on distinctive, although similar, tri-disulfide linkages in the peptides. -def SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen 13 aa peptide from mouse MBD-3 (MBD31-P) and 15-aa peptide from HBD-3, HBD31-P (the mixture designated HBD31-P; control peptides) were coupled to KLH. Epitope location ~ N-terminus of mature defensin-3 (1) SpCrossreactivity The HBD31-P and MBD31-P control peptides are specific for human and mouse defensin-3. No significant homology exists with other beta-defensins. The HBD31-P control peptide is available for antibody blocking to confirm specificity of antibodies. It is not suitable for testing by Western due to small size. Antibody cross-reactivity in various species has not been studied For research use only, not for diagnostic or therapeutic use.