Alpha Diagnostic International, Inc. Anti-Human beta-Defensin 1 (BD-1/hBD-1) antiserum #1 HBD12-S

Anti-Human beta-Defensin 1 (BD-1/hBD-1) antiserum #1 General Information Antimicrobial peptides are a common mechanism of host defense utilized by a variety of species, from insects to humans. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defe SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Human SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Antiserum Unpurified SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen A 17 AA Peptide (designated HBD12-P; control peptide) Epitope location Near the N-terminus of mature human defensin-1 conjugated to KLH SpCrossreactivity The HBD12-P sequence is 94% conserved in monkey beta deffensin-1. No significant homology exists with mouse or rat defensin-1 or other beta-defensins (2-4). We recommend the use of antibody Cat # MBD11 that is made to mouse defensin-1 peptide for the detection of mouse beta-defensin-1. Antibody cross-reactivity in various species has not been studied. For research use only, not for diagnostic or therapeutic use.