Alpha Diagnostic International, Inc. Rat Chloride channel 1 (CLC1) Control/blocking peptide # 1 CLC11-P

Rat Chloride channel 1 (CLC1) Control/blocking peptide # 1 General Information Rat CLC-1 is 994 aa membrane protein (human CLC-1 988 aa) (1). It is predominantly expressed in skeletal muscles. Defects in CLC1 (CLCN1) are the cause of autosomal recessive generalized myotonia (Becker's disease) (RGM) and autosomal dominant myotonia SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Rat/Mouse/Human Form Antigen/blocking Peptide Antigen 18-aa peptide of rat CLC1 A; Designated (CLC11-P or control peptide/blocking peptide) conjugated to KLH; epitope location ~C-terminus, extracellular domain SpCrossreactivity The 18 AA rat CLC11-P control peptide 100% conserved in mouse, dog, rat, and human CLC-1. No significant sequence homology is detected with other CLCs or other proteins. Antibody cross-reactivity in various species has not been studied For research use only, not for diagnostic or therapeutic use.