Alpha Diagnostic International, Inc. Anti-Human Calcitonin Gene Related Peptide (CGRP) Control/blocking peptide #1 CGRP11-P

Anti-Human Calcitonin Gene Related Peptide (CGRP) Control/blocking peptide #1 General Information The calcitonin family of bioactive peptides comprises of calcitonin, amylin, two calcitonin-gene related peptides (CGRP1, and CGRP2) and adrenomedullin (ADM). Calcitonin is 32 aa peptide found in the parafollicular ?C? cells of the thyroid in mammals. I SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen 19-aa peptide of Human CGRP/CALCA (protein accession # P10092, refs 1; Designated (CGRP11-P or control peptide) near the N-terminus SpCrossreactivity The human CGRP11-P is quite conserved in various species: equine, sheep, pig, canine, rat, mouse, bovine, frog, monkey, chicken, zebra fish (84-95%). There is just 1 aa change between the human CGRP1 and CGRP2. Significant sequence homology is also found with amylin. However, no significant sequence homology is detected with calcitonin or adrenomedullin. Antibody cross-reactivity in various species has not been studied For research use only, not for diagnostic or therapeutic use.