Alpha Diagnostic International, Inc. Anti-Human beta-site APP cleaving enzyme (BACE2/Asp1) antiserum #1 BACE21-S

Anti-Human beta-site APP cleaving enzyme (BACE2/Asp1) antiserum #1 General Information BACE2 or Asp1/Memapsin2 (human 518, mouse 514 aa) resides in the obligate Down Syndrome regions of chromosome 21. BACE2, 52% identity with BACE/Asp2, is most divergent at the N and C-terminus, but display the same protein topology as BACE. BACE2, like B SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Human SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Antiserum Unpurified SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen 10-aa peptide of human BACE2/Asp1; Designated (BACE21-P or control peptide) conjugated to KLH; Epitope location~ C-terminal, Cytoplasmic domain SpCrossreactivity The human BACE21-P peptide sequence is 100% conserved in mouse and rat BACE/Asp2. No significant sequence homology exists with BACE2/Aps1, a homolog of BACE, or other Asps. Antibody crossreactivity in various species is not established. For research use only, not for diagnostic or therapeutic use.