Alpha Diagnostic International, Inc. Human beta-site APP cleaving enzyme (BACE/Asp2) Control/blocking peptide #1 BACE11-P

Human beta-site APP cleaving enzyme (BACE/Asp2) Control/blocking peptide #1 General Information -amyloid (A ) deposition in the brain is the hallmark of Alzheimer's Disease (AD). To initiate A formation, -secretase cleaves APP at the N-terminus of A to release APPs (~100 kDa soluble NT-fragment), and C99, a 12-kDa CT membrane fragment. Altern SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen 17-aa peptide of Human BACE/Asp2 ; Designated (BACE11-P or control peptide) conjugated to KLH; epitope location ~ C-terminus SpCrossreactivity The human BACE11-P peptide sequence has high degree of homology (93%) with mouse and rat BACE/Asp2. No significant sequence homology exists with BACE2/Aps1, a homolog of BACE, or other Asps. Antibody crossreactivity in various species is not established For research use only, not for diagnostic or therapeutic use.