Alpha Diagnostic International, Inc. Human Amyloid precursor protein (APP) control/blocking peptide #2 APP12-P

Human Amyloid precursor protein (APP) control/blocking peptide #2 General Information APP gene has 19 exons (1). At least 8 different types of APP (APP695, APP751, and APP770 are the major ones) are produced as a result of alternative splicing of exons 7, 8, and 15. Exons 7 codes for a 57-aa domain that is analogous to Kunitz protease in SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen 20aa peptide of Human APP695 ; Designated (APP12-P or control peptide). Epitope location ~ N-terminal, Extracellular SpCrossreactivity The human APP12-P peptide sequence is found in all major APP isoforms (APP695, APP751, and APP770). It is 95% identical to pig, mouse, and rat, 90% with chicken APPs. Antibody crossreactivity in various species is not established For research use only, not for diagnostic or therapeutic use.