Alpha Diagnostic International, Inc. Recombinant (E coli) Purified Human Apolipoprotein E3 protein APOE36-R

Recombinant (E coli) Purified Human Apolipoprotein E3 protein General Information Apolipoprotein E (apo E), a component of lipoproteins produced by the liver and in circulating macrophages, plays a critical role in the reverse transport of cholesterol to the liver via the circulation. ApoE is also expressed in the brain and in response to injury in both the peripheral and central nervous systems. ApoE is a single polypeptide chain of 299 amino acids (~34 kDa) consisting of two independently folded functional domains. The C-terminal domain contains the major lipid-binding region. ApoE is a high-affinity ligand for the low density lipoprotein receptor (LDLR) family and for cell-surface heparan sulfate proteoglycans. In humans, apoE has three major isoforms: Apo E2 (Cys112, Cys158), Apo E3 (Cys112, Arg158), Apo E4 (Arg112, Arg158), products of alleles at a single gene locus. Although apoE4 is neither necessary nor sufficient to cause AD, inheritance of apoE4 is a significant risk factor for late onset AD, decreasing the age of onset and the duration of disease. Due primarily to this genetic linkage, the role of apoE in the pathogenesis AD is being actively studied. SpeciesReactivity Human Antigen Protein Recomb. Form Protein Control For research use only, not for diagnostic or therapeutic use.