Alpha Diagnostic International, Inc. Anti-Human Anion Exchanger 4 (AE4) IgG #1, aff pure AE41-A

Anti-Human Anion Exchanger 4 (AE4) IgG #1, aff pure General Information Human AE4 (945 aa; chromosome 5) has 14 TM domains. It is strongly expressed in the kidney. Rabbit and human AE4 share 84% identity. AE4 has at least 3 alternatively spliced isoforms: (Isoform 1, 983 aa; isoform 2, 945-aa; missing 77-100, 384-394, 592- SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Human SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Affinity purified IgG SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen 15-aa peptide of Human AE4 (protein accession #Q96Q91, refs 1); Designated (AE41-P or Control peptide) conjugated to KLH epitope location ~ C-terminal, Cytoplasmic SpCrossreactivity Human AE41-P control peptide is 100% conserved in human isoforms 1-3, rat, rabbit AE4. The sequence is also the same in proteins listed as human NBC5 (gene accession # AB032762, 657 aa) and NBC (gene accession # AF313465, 990 aa; XM_038736, 959 aa). No significant sequence homology of AE41-P is detected with other AE1-3 or other transporters. Antibody cross-reactivity in various species is not known For research use only, not for diagnostic or therapeutic use.