Mouse monoclonal Cathepsin H antibody Background: Cathepsin H is a lysosomal glycoprotein and a member of the cysteine proteinase class. This cysteine protease class comprises cathepsin B, H, k, L, and O. These proteinases are viewed as simple mediators of lysosomal protein degradation. Cathepsin H is synthesized as an inactive proenzyme (41 kDa) and then proteolytically processed to an active single chain, mature form (28 kDa) within the endosomes/lysosomes. This proteinase is a peptidehydrolase that was first isolated from rat liver, and then identified in liver, kidney, spleen, and brain of different mammals. Furthermore, cathepsin H is increased in disease states including breast carcinoma, melanoma, gliomas, and colorectal and prostate carcinoma.
Mouse monoclonal Cathepsin H antibody
Background:
Cathepsin H is a lysosomal glycoprotein and a member of the cysteine proteinase class. This cysteine protease class comprises cathepsin B, H, k, L, and O. These proteinases are viewed as simple mediators of lysosomal protein degradation. Cathepsin H is synthesized as an inactive proenzyme (41 kDa) and then proteolytically processed to an active single chain, mature form (28 kDa) within the endosomes/lysosomes. This proteinase is a peptidehydrolase that was first isolated from rat liver, and then identified in liver, kidney, spleen, and brain of different mammals. Furthermore, cathepsin H is increased in disease states including breast carcinoma, melanoma, gliomas, and colorectal and prostate carcinoma.
