A hermetic cell culture centrifuge, the Culturefuge is designed for gentle harvesting of shear-sensitive material in applications involving mammalian cell cultures and precipitated proteins.
Gentle product acceleration
The Culturefuge cell culture centrifuge is a hygienic clarification system for the gentle treatment of cell cultures and other shear-sensitive biological material. The unique hollow spindle enables gentle acceleration of the feed liquid to the rotational speed of the centrifuge, thereby minimizing cell lysis. This prevents the release of unwanted intracellular proteins or minimizes the destruction of fragile protein precipitates. Yields are thus enhanced and downstream operations optimized.
Scalable cell culture centrifuge
Ideal for cell culture fermentation and continuous cell harvesting under hermetic conditions, the Culturefuge delivers consistent product quality and can be accurately and reliably scaled up from use in laboratories and pilot plants to full-scale production.
Airtight cell culture centrifuge
The Culturefuge is a fully hermetic centrifuge, which effectively eliminates any air-liquid interface inside the separator bowl. This prevents air entrainment, which can cause problems in the downstream filtration process. Furthermore, flow control devices can be located downstream thus enabling implementation of an obstruction-free, full-bore feed arrangement.
Hygienic centrifuge design
Culturefuge is engineered using materials that meet stringent regulatory requirements for processing. To maintain hygienic operating conditions, this cell culture centrifuge can be automatically cleaned and sanitized without requiring major disassembly or assembly using Sterilization-in-Place (SIP) and Cleaning-in-Place (CIP) systems. In addition, flushing nozzles spray outside the centrifuge bowl, cyclone and inside the frame hood for maximum hygiene.
- Culturefuge 100 for pilot plants and small-scale production facilities with capacities ranging from 200 to 2,000 l/hr.
- Culturefuge 300 for production with capacities ranging from 2,000 to 8,000 l/hr.
- Culturefuge 400 for production with capacities ranging from 5,000 to 20,000 l/hr.